814 SLEEP DISORDERS AND DYSBIOSIS: CULPRITS IN CARDIOVASCULAR DISEASES

Abstract Introduction Primary prevention of cardiovascular disease, the leading cause death worldwide, has become a mainstay in addressing this considerable global challenge. It clear that gut microbiome plays vital role human metabolism, immunity, and reactions to diseases, including disease. Growing evidence suggests sleep quality can be influenced by Gut Microbiome (GM), since probiotic supplementation been found improve subjective healthy. Disruption sleep/wake functions associated with both short (increased stress responsivity or psychosocial issues) long term health consequences, cancer diseases. Emerging disturbance circadian rhythm, which incorporates essential physiological humoral 24-hour cycle, could an understudied risk factor for While impaired is significant contributor rhythm disturbance, regarding interventions their effect on events lacking. We conduct literature review synthesize body interaction between GM order achieve robust broad conclusions implications system. Methods reviewed relationship sleep, from January 2017 up until August 2022. Results The influence through bidirectional communication channel linking brain gut, Brain-Gut-Microbiome Axis (BGMA). Many authors have described several underlying factors involved sleep-disorder, such as immune system, vagus nerve (VN), neuroendocrine bacterial metabolites. Furthermore, targeting proved beneficial amelioration problems: gamma-amino butyric acid (GABA) produced intestinal microbiota may central nervous system VN some studies reported Conclusions Sleep constitute novel target preventive intervention. More research well-designed are needed better evaluate multi-directional diet CVD. From our analysis provides wide range potential therapeutic targets. Challenges ahead include development reversing dysbiosis, at early stage, combined good behavior, open new horizons prevent